Treatment with oral corticosteroids was initiated, which resulted in a
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A dramatic improvement in two days. The plaques disappeared, the fever subsided, and the pain decreased rapidly. What exactly is candy syndrome?
Acute febrile neutrophilic dermatosis shown by a medical animation image
Sweet’s syndrome, or acute febrile neutrophilic dermatosis , is a rare immune-mediated skin condition, first described in 1964 by Dr. Robert Sweet. It is characterized by:
Sudden, painful red or purple plaques or papules
The injuries were concentrated on the face, neck, torso, and hands.
It is accompanied by fever, fatigue, and joint pain.
Elevated white blood cell count, especially neutrophils
Known triggers
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The exact cause is not fully understood, but it appears to be related to immune system dysregulation. Triggers include:
Infections (respiratory or gastrointestinal)
Hematological cancers, such as acute myeloid leukemia
Autoimmune or inflammatory diseases
Medications (antibiotics, antiepileptics, G-CSF, some vaccines)
Treatment usually involves systemic corticosteroids, which typically provide rapid relief.
Why this case stands out
What is atopic dermatitis? Causes and treatment? – Dermalogica Vietnam
The most surprising aspect of this case is that Sweet’s syndrome was triggered by an inhaled COPD medication . Until now, no case in the medical literature had linked the condition to inhaled therapies.
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Clinical significance
Expanding the known triggers : Previously, Sweet’s syndrome was primarily associated with oral or injectable drugs. This case demonstrates that even inhaled medications can trigger rare immune responses.
Diagnostic challenges : Due to its rarity, the condition can easily be mistaken for more common skin rashes. Early biopsy is essential.
