A well-known over-the-counter drug found in homes across America may be more dangerous than people realize. Tylenol PM, a common nighttime pain reliever, can lead to organ failure if taken too often or in high doses.
The warning comes from Dr. Ethan Melillo, a pharmacist from Rhode Island, who recently shared his concerns online. He warns that many people assume Tylenol PM is harmless because it’s sold over the counter.
Let’s explore what makes this acetaminophen-based sleep aid potentially harmful, and what safer alternatives are available.
What’s in Tylenol PM?
Tylenol PM contains two active ingredients:
Acetaminophen, which relieves pain and reduces fever
Diphenhydramine, an antihistamine known for its sedative effects
This over-the-counter sleep and pain reliever helps users fall asleep while also relieving mild aches and pains. Many people use it for discomfort that keeps them awake at night. While it may seem like a simple solution, frequent use can pose serious risks to liver and kidney health.
Hidden Risks to Liver and Kidney Health
Dr. Melillo’s message focuses on how regular use of Tylenol PM can damage internal organs. He explains that the combination of acetaminophen and diphenhydramine increases the risk of long-term damage, especially if used incorrectly.
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Paracetamol and Liver Damage
Paracetamol is generally safe in the right dosage. However, more than 4,000 milligrams per day can cause acute liver failure. People with liver disease or those who drink alcohol face an even greater risk.
In the United States, acetaminophen is one of the leading causes of liver failure. Many people accidentally exceed the safe dose by taking multiple products containing it.
Sick woman suffering from pain in the bathroom and illustration of an unhealthy liver. Hepatitis disease
Source: Shutterstock
Diphenhydramine and its effects
Diphenhydramine helps with sleep and allergies, but long-term use can cause confusion, dizziness, and memory problems, especially in the elderly. Some research also suggests that it may affect kidney function.
Medications like Tylenol PM, which includes this over-the-counter sleep aid, are not meant to be taken daily. Their sedative effects can quickly shift from helpful to harmful.
Read more: New study finds common medications may reduce dementia risk
Why many people abuse Tylenol PM without realizing it
A major concern is that most people don’t realize how easy it is to abuse this drug. Because Tylenol PM is widely available and well-known, it feels safe.
Boxes of Tylenol pain relievers are up close on a shelf. It was at a DOLLAR TREE in Hutchinson, Kansas, USA. It was 7/4/2024.
Source: Shutterstock
This trust can be misguided. For example, someone might take Tylenol PM to sleep and also take a cold medicine that contains acetaminophen. Without reading the labels, they could inadvertently exceed the daily limit.
Diphenhydramine presents another problem. Regular use can create tolerance, meaning the same dose becomes less effective. Users then increase the amount or frequency, increasing health risks.
This casual reliance on nighttime painkillers often leads to long-term use without understanding the consequences.
Read more: Millions who use popular sleep drugs at night may face increased risk of disability
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